RHOF auto-activates

Stable Identifier
R-HSA-9693111
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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RHOF auto-activates
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RHOF (Rif) possesses an elevated intrinsic guanine nucleotide exchange activity (Jaiswal, Fansa et al. 2013). As GTP is more abundant in cells than GDP (Traut 1994), the exchange of guanine nucleotide on RHOF is spontaneous and insensitive to the presence of EDTA. RHOF is thought to be present in a constitutively active state (Jaiswal, Fansa et al. et al. 2013).
Literature References
PubMed ID Title Journal Year
23096567 New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm

Jaiswal, M, Fansa, EK, Dvorsky, R, Ahmadian, MR

Biol. Chem. 2013
Participants
Input
Output
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as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOF:GDP [plasma membrane]

Physical Entity
RHOF:GDP [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
RHOF auto-activates (Bos taurus)
RHOF auto-activates (Caenorhabditis elegans)
RHOF auto-activates (Canis familiaris)
RHOF auto-activates (Danio rerio)
RHOF auto-activates (Drosophila melanogaster)
RHOF auto-activates (Gallus gallus)
RHOF auto-activates (Mus musculus)
RHOF auto-activates (Rattus norvegicus)
RHOF auto-activates (Saccharomyces cerevisiae)
RHOF auto-activates (Schizosaccharomyces pombe)
RHOF auto-activates (Sus scrofa)
RHOF auto-activates (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2020-07-14)
Reviewed
Fort, P  (2021-02-05)
Bisbal, M  (2021-02-20)
Created
Orlic-Milacic, M  (2020-06-29)
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