RHOF auto-activates

Stable Identifier
R-HSA-9693111
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RHOF (Rif) is an atypical RHO GTPase that possesses an elevated intrinsic guanine nucleotide exchange activity (Jaiswal, Fansa et al. 2013). As GTP is more abundant in cells than GDP (Traut 1994), the exchange of guanine nucleotide on RHOF is spontaneous and insensitive to the presence of EDTA. RHOF is thought to be present in a constitutively active state (Jaiswal, Fansa et al. et al. 2013).

Literature References
PubMed ID Title Journal Year
23096567 New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm

Jaiswal, M, Fansa, EK, Dvorsky, R, Ahmadian, MR

Biol. Chem. 2013
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOF:GDP [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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