Expression of AMH in testis differentiation

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R-HSA-9693009
Type
Reaction [uncertain]
Species
Homo sapiens
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In differentiating Sertoli cells of the testis, the AMH gene is transcribed to yield mRNA and the mRNA is translated to yield AMH protein (De Santa Barbara et al. 1998, Rahmoun et al. 2017, and inferred from mouse homologs). SOX9, NR5A1 (SF1), and GATA4 bind the promoter of the AMH gene and activate transcription (De Santa Barbara et al. 1998, Rahmoun et al. 2017, and inferred from mouse homologs). AMH is secreted and acts via the AMHR receptor to suppress formation of the Mullerian duct.

Literature References
PubMed ID Title Journal Year
28472341 In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

Symon, A, Philip, GK, Chung, J, Clair, P, Boizet-Bonhoure, B, Bardwell, V, Rahmoun, M, Poulat, F, Murphy, M, Bagheri-Fam, S, Lavery, R, Rossitto, M, Laurent-Chaballier, S, Zarkower, D, Pailhoux, E, Bellora, N, Harley, VR, Cammas, F

Nucleic Acids Res. 2017
9774680 Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone gene

Moniot, B, Bonneaud, N, Poulat, F, De Santa Barbara, P, Berta, P, Desclozeaux, M, Sudbeck, P, Scherer, G, Boizet, B

Mol. Cell. Biol. 1998
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