SARS-CoV-1-host interactions

Stable Identifier
R-HSA-9692914
Type
Pathway
Species
Homo sapiens
Related Species
Human SARS coronavirus
ReviewStatus
5/5
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Coronaviruses are a group of enveloped viruses with single‑stranded, positive‑sense RNA genomes. Each of the steps of viral replication - attachment and entry, translation of viral replicase, genome transcription and replication, translation of structural proteins, and virion assembly and release - involves host factors. These interactions can cause alterations in cellular structure and physiology, and activate host stress responses, autophagy, cell death, and processes of innate immunity (Fung TS & Liu DX 2019). This Reactome module describes molecular mechanisms by which severe acute respiratory syndrome coronavirus type 1 (SARS-CoV-1) modulates host cell death pathways, innate immune responses, translation, intracellular signaling and regulatory pathways, and PDZ-mediated cell-cell junctions.
Literature References
PubMed ID Title Journal Year
33060197 Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Gordon, DE, Hiatt, J, Bouhaddou, M, Rezelj, VV, Ulferts, S, Braberg, H, Jureka, AS, Obernier, K, Guo, JZ, Batra, J, Kaake, RM, Weckstein, AR, Owens, TW, Gupta, M, Pourmal, S, Titus, EW, Cakir, M, Soucheray, M, McGregor, M, Cakir, Z, Jang, G, O'Meara, MJ, Tummino, TA, Zhang, Z, Foussard, H, Rojc, A, Zhou, Y, Kuchenov, D, Hüttenhain, R, Xu, J, Eckhardt, M, Swaney, DL, Fabius, JM, Ummadi, M, Tutuncuoglu, B, Rathore, U, Modak, M, Haas, P, Haas, KM, Naing, ZZC, Pulido, EH, Shi, Y, Barrio-Hernandez, I, Memon, D, Petsalaki, E, Dunham, A, Marrero, MC, Burke, D, Koh, C, Vallet, T, Silvas, JA, Azumaya, CM, Billesbølle, C, Brilot, AF, Campbell, MG, Diallo, A, Dickinson, MS, Diwanji, D, Herrera, N, Hoppe, N, Kratochvil, HT, Liu, Y, Merz, GE, Moritz, M, Nguyen, HC, Nowotny, C, Puchades, C, Rizo, AN, Schulze-Gahmen, U, Smith, AM, Sun, M, Young, ID, Zhao, J, Asarnow, D, Biel, J, Bowen, A, Braxton, JR, Chen, J, Chio, CM, Chio, US, Deshpande, I, Doan, L, Faust, B, Flores, S, Jin, M, Kim, K, Lam, VL, Li, F, Li, J, Li, YL, Li, Y, Liu, X, Lo, M, Lopez, KE, Melo, AA, Moss, FR, Nguyen, P, Paulino, J, Pawar, KI, Peters, JK, Pospiech, TH, Safari, M, Sangwan, S, Schaefer, K, Thomas, PV, Thwin, AC, Trenker, R, Tse, E, Tsui, TKM, Wang, F, Whitis, N, Yu, Z, Zhang, K, Zhang, Y, Zhou, F, Saltzberg, D, QCRG Structural Biology Consortium, -, Hodder, AJ, Shun-Shion, AS, Williams, DM, White, KM, Rosales, R, Kehrer, T, Miorin, L, Moreno, E, Patel, AH, Rihn, S, Khalid, MM, Vallejo-Gracia, A, Fozouni, P, Simoneau, CR, Roth, TL, Wu, D, Karim, MA, Ghoussaini, M, Dunham, I, Berardi, F, Weigang, S, Chazal, M, Park, J, Logue, J, McGrath, M, Weston, S, Haupt, R, Hastie, CJ, Elliott, M, Brown, F, Burness, KA, Reid, E, Dorward, M, Johnson, C, Wilkinson, SG, Geyer, A, Giesel, DM, Baillie, C, Raggett, S, Leech, H, Toth, R, Goodman, N, Keough, KC, Lind, AL, Zoonomia Consortium, -, Klesh, RJ, Hemphill, KR, Carlson-Stevermer, J, Oki, J, Holden, K, Maures, T, Pollard, KS, Sali, A, Agard, DA, Cheng, Y, Fraser, JS, Frost, A, Jura, N, Kortemme, T, Manglik, A, Southworth, DR, Stroud, RM, Alessi, DR, Davies, P, Frieman, MB, Ideker, T, Abate, C, Jouvenet, N, Kochs, G, Shoichet, B, Ott, M, Palmarini, M, Shokat, KM, García-Sastre, A, Rassen, JA, Grosse, R, Rosenberg, OS, Verba, KA, Basler, CF, Vignuzzi, M, Peden, AA, Beltrao, P, Krogan, NJ

Science 2020
31226023 Human Coronavirus: Host-Pathogen Interaction

Fung, TS, Liu, DX

Annu. Rev. Microbiol. 2019
Participants
Participates
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Cross References
Mondo
Authored
Reviewed
Created
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