CDC42 binds effectors at the ER membrane

Stable Identifier
R-HSA-9692809
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated GTP-bound CDC42 binds to kinectin (KTN1) at the endoplasmic reticulum membrane (Hotta et al. 1996).

Active CDC42 also binds the following candidate effectors at the endoplasmic reticulum membrane identified in the screen by Bagci et al. 2020:
LBR (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
8769096 Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor

Hotta, K, Tanaka, K, Mino, A, Kohno, H, Takai, Y

Biochem. Biophys. Res. Commun. 1996
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!