CDC42 binds effectors at the ER membrane

Stable Identifier
R-HSA-9692809
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
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CDC42 binds effectors at the ER membrane
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Activated GTP-bound CDC42 binds to kinectin (KTN1) at the endoplasmic reticulum membrane (Hotta et al. 1996).

Active CDC42 also binds the following candidate effectors at the endoplasmic reticulum membrane identified in the screen by Bagci et al. 2020:
LBR (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
8769096 Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor

Hotta, K, Tanaka, K, Mino, A, Kohno, H, Takai, Y

Biochem. Biophys. Res. Commun. 1996
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
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Output
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Orthologous Events
CDC42 binds effectors at the ER membrane (Canis familiaris)
CDC42 binds effectors at the ER membrane (Danio rerio)
CDC42 binds effectors at the ER membrane (Gallus gallus)
CDC42 binds effectors at the ER membrane (Mus musculus)
CDC42 binds effectors at the ER membrane (Rattus norvegicus)
CDC42 binds effectors at the ER membrane (Sus scrofa)
Authored
Orlic-Milacic, M  (2020-07-14)
Rothfels, K  (2020-07-14)
Reviewed
Fort, P  (2021-02-05)
Created
Orlic-Milacic, M  (2020-06-25)
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