The transcription factors WT1 (Shimamura et al. 1997, Hossain and Saunders 2001, Miyamoto et al. 2008, also inferred from mouse homologs), NR5A1 (also called SF1) (De Santa Barbara et al. 2001), GATA4:ZFPM2 (also called GATA4:FOG2) (Miyamoto et al. 2008, also inferred from mouse homologs) bind the promoter of the SRY gene and activate transcription of SRY. SRY is a mammal-specific gene located on the Y chromosome that is responsible for male sex determination.