WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene

Stable Identifier
R-HSA-9692250
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The transcription factors WT1 (Shimamura et al. 1997, Hossain and Saunders 2001, Miyamoto et al. 2008, also inferred from mouse homologs), NR5A1 (also called SF1) (De Santa Barbara et al. 2001), GATA4:ZFPM2 (also called GATA4:FOG2) (Miyamoto et al. 2008, also inferred from mouse homologs) bind the promoter of the SRY gene and activate transcription of SRY. SRY is a mammal-specific gene located on the Y chromosome that is responsible for male sex determination.

Literature References
PubMed ID Title Journal Year
18445271 A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation

Taniguchi, H, Viger, RS, Miyamoto, Y, Silversides, DW, Hamel, F

BMC Mol. Biol. 2008
11207191 Steroidogenic factor-1 contributes to the cyclic-adenosine monophosphate down-regulation of human SRY gene expression

Moniot, B, De Santa Barbara, P, Berta, P, Méjean, C, Boizet-Bonhoure, B, Malclès, MH

Biol. Reprod. 2001
11278460 The human sex-determining gene SRY is a direct target of WT1

Hossain, A, Saunders, GF

J. Biol. Chem. 2001
9815658 The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor

Fraizer, GC, Saunders, GF, Shimamura, R, Lau, Y.C., Trapman, J

Clin. Cancer Res. 1997
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