In the gonadal ridge (genital ridge), the SRY gene is transcribed to yield mRNA and the mRNA is translated to yield SRY protein (De Santa Barbara et al. 2001, Hossain end Saunders 2001, Miyamoto et al. 2008, also inferred from mouse homologs). Transcription of SRY is activated by WT1 (Hossain and Saunders 2001, Miyamoto et al. 2008), GATA4:ZFPM2 (also called GATA4:FOG2) (Miyamoto et al. 2008), and NR5A1 (also called SF1) (De Santa Barbara et al. 2001).
Taniguchi, H, Viger, RS, Miyamoto, Y, Silversides, DW, Hamel, F
Moniot, B, De Santa Barbara, P, Berta, P, Méjean, C, Boizet-Bonhoure, B, Malclès, MH
Hossain, A, Saunders, GF
© 2023 Reactome
