Reactome | Expression of SRY in testis differentiation

Expression of SRY in testis differentiation

Stable Identifier

R-HSA-9692241

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Expression of SRY in testis differentiation

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In the gonadal ridge (genital ridge), the SRY gene is transcribed to yield mRNA and the mRNA is translated to yield SRY protein (De Santa Barbara et al. 2001, Hossain end Saunders 2001, Miyamoto et al. 2008, also inferred from mouse homologs). Transcription of SRY is activated by WT1 (Hossain and Saunders 2001, Miyamoto et al. 2008), GATA4:ZFPM2 (also called GATA4:FOG2) (Miyamoto et al. 2008), and NR5A1 (also called SF1) (De Santa Barbara et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
18445271	A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation Taniguchi, H, Viger, RS, Miyamoto, Y, Silversides, DW, Hamel, F	BMC Mol. Biol.	2008
11207191	Steroidogenic factor-1 contributes to the cyclic-adenosine monophosphate down-regulation of human SRY gene expression Moniot, B, De Santa Barbara, P, Berta, P, Méjean, C, Boizet-Bonhoure, B, Malclès, MH	Biol. Reprod.	2001
11278460	The human sex-determining gene SRY is a direct target of WT1 Hossain, A, Saunders, GF	J. Biol. Chem.	2001