Expression of SRY in testis differentiation

Stable Identifier
Reaction [uncertain]
Homo sapiens
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In the gonadal ridge (genital ridge), the SRY gene is transcribed to yield mRNA and the mRNA is translated to yield SRY protein (De Santa Barbara et al. 2001, Hossain end Saunders 2001, Miyamoto et al. 2008, also inferred from mouse homologs). Transcription of SRY is activated by WT1 (Hossain and Saunders 2001, Miyamoto et al. 2008), GATA4:ZFPM2 (also called GATA4:FOG2) (Miyamoto et al. 2008), and NR5A1 (also called SF1) (De Santa Barbara et al. 2001).

Literature References
PubMed ID Title Journal Year
18445271 A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation

Taniguchi, H, Viger, RS, Miyamoto, Y, Silversides, DW, Hamel, F

BMC Mol. Biol. 2008
11207191 Steroidogenic factor-1 contributes to the cyclic-adenosine monophosphate down-regulation of human SRY gene expression

Moniot, B, De Santa Barbara, P, Berta, P, Méjean, C, Boizet-Bonhoure, B, Malclès, MH

Biol. Reprod. 2001
11278460 The human sex-determining gene SRY is a direct target of WT1

Hossain, A, Saunders, GF

J. Biol. Chem. 2001
This event is regulated
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