Expression of DHH in testis differentiation

Stable Identifier
Reaction [uncertain]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The DHH gene is transcribed to yield mRNA and the mRNA is translated to yield DHH protein (Rahmoun et al. 2017 and inferred from mouse homologs). Transcription of DHH is directly activated by SOX9 (inferred from mouse homologs). DHH is secreted from pre-Sertoli cells (Rahmoun et al. 2017 and inferred from mouse homologs) and acts via the PTCH1 receptor to regulate testis development.

Literature References
PubMed ID Title Journal Year
28472341 In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

Rahmoun, M, Lavery, R, Laurent-Chaballier, S, Bellora, N, Philip, GK, Rossitto, M, Symon, A, Pailhoux, E, Cammas, F, Chung, J, Bagheri-Fam, S, Murphy, M, Bardwell, V, Zarkower, D, Boizet-Bonhoure, B, Clair, P, Harley, VR, Poulat, F

Nucleic Acids Res. 2017
Participant Of
This event is regulated
Inferred From
Cite Us!