Expression of DHH in testis differentiation

Stable Identifier
R-HSA-9692146
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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Expression of DHH in testis differentiation
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The DHH gene is transcribed to yield mRNA and the mRNA is translated to yield DHH protein (Rahmoun et al. 2017 and inferred from mouse homologs). Transcription of DHH is directly activated by SOX9 (inferred from mouse homologs). DHH is secreted from pre-Sertoli cells (Rahmoun et al. 2017 and inferred from mouse homologs) and acts via the PTCH1 receptor to regulate testis development.
Literature References
PubMed ID Title Journal Year
28472341 In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

Symon, A, Philip, GK, Chung, J, Clair, P, Boizet-Bonhoure, B, Bardwell, V, Rahmoun, M, Poulat, F, Murphy, M, Bagheri-Fam, S, Lavery, R, Rossitto, M, Laurent-Chaballier, S, Zarkower, D, Pailhoux, E, Bellora, N, Harley, VR, Cammas, F

Nucleic Acids Res. 2017
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SOX9:DHH gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Dhh in testis differentiation (Mus musculus)
Authored
May, B  (2020-06-15)
Reviewed
Imaimatsu, K  (2020-10-29)
Kanai, Y  (2020-10-29)
Created
May, B  (2020-06-20)
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