nsp7 binds nsp8

Stable Identifier
R-HSA-9691335
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
nsp7 binds nsp8
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SARS-CoV-2 nonstructural proteins nsp7 and nsp8 form a heterodimer (Gao et al. 2020, Li et al. 2020; Xu et al, 2021). A dimer of dimers has also been observed and it has been proposed that this heterotetramer forms a putative RNA-binding site, but cryo-EM studies suggest that the heterotetramer can dissociate into a stable dimeric unit that might bind to nsp12 in the RTC (Konkolova et al. 2020; Couruble et al, 2021).
Literature References
PubMed ID Title Journal Year
32838362 Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis

Li, J, Guo, M, Tian, X, Wang, X, Yang, X, Wu, P, Liu, C, Xiao, Z, Qu, Y, Yin, Y, Wang, C, Zhang, Y, Zhu, Z, Liu, Z, Peng, C, Zhu, T, Liang, Q

Med (N Y) 2020
32277040 Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Gao, Y, Yan, L, Huang, Y, Liu, F, Zhao, Y, Cao, L, Wang, T, Sun, Q, Ming, Z, Zhang, L, Ge, J, Zheng, L, Zhang, Y, Wang, H, Zhu, Y, Zhu, C, Hu, T, Hua, T, Zhang, B, Yang, X, Li, J, Yang, H, Liu, Z, Xu, W, Guddat, LW, Wang, Q, Lou, Z, Rao, Z

Science 2020
34297909 Compartmentalization-aided interaction screening reveals extensive high-order complexes within the SARS-CoV-2 proteome

Xu, W, Pei, G, Liu, H, Ju, X, Wang, J, Ding, Q, Li, P

Cell Rep 2021
34121407 Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics

Courouble, VV, Dey, SK, Yadav, R, Timm, J, Harrison, JJEK, Ruiz, FX, Arnold, E, Griffin, PR

J Am Soc Mass Spectrom 2021
32531208 Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2

Peng, Q, Peng, R, Yuan, B, Zhao, J, Wang, M, Wang, X, Wang, Q, Sun, Y, Fan, Z, Qi, J, Gao, GF, Shi, Y

Cell Rep 2020
32438371 Structure of replicating SARS-CoV-2 polymerase

Hillen, HS, Kokic, G, Farnung, L, Dienemann, C, Tegunov, D, Cramer, P

Nature 2020
32535228 Structural analysis of the putative SARS-CoV-2 primase complex

Konkolova, E, Klima, M, Nencka, R, Boura, E

J. Struct. Biol. 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Orlic-Milacic, M  (2020-08-12)
Senff-Ribeiro, A  (2020-08-12)
Reviewed
Acencio, ML  (2020-09-09)
Created
Orlic-Milacic, M  (2020-06-11)
Cite Us!