RAC1 binds effectors at the ER membrane

Stable Identifier
R-HSA-9691174
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In its GTP bound active form, endoplasmic reticulum membrane associated RAC1 binds to and activates KTN1 (Hotta et al. 1996).

The following endoplasmic reticulum proteins have been identified as putative RAC1 effectors in the high throughput screen by Bagci et al. 2020 and are annotated as candidate RAC1 effectors:
EMD (Bagci et al. 2020)
ESYT1 (Bagci et al. 2020)
LBR (Bagci et al. 2020)
LEMD3 (Bagci et al. 2020)
VRK2 (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
8769096 Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor

Hotta, K, Tanaka, K, Mino, A, Kohno, H, Takai, Y

Biochem. Biophys. Res. Commun. 1996
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
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