Reactome | CYSLTR1 binds LTC4,LTD4,LTE4

CYSLTR1 binds LTC4,LTD4,LTE4

Stable Identifier

R-HSA-9690439

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Leukotriene receptors (Homo sapiens)
        
        CYSLTR1 binds LTC4,LTD4,LTE4 (Homo sapiens)

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The cysteinyl-leukotrienes are potent smooth muscle contractile agents mediating bronchoconstriction. Examples are LTC4, LTD4 and LTE4. There are two human cysteinyl-leukotriene receptors, CYSLTR1 (Lynch et al. 1999) and CYSLTR2. They mediate their effects via coupling to the G protein alpha q/11 subunit (Sarau et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10462554	Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor Jenkins, O, Muir, AI, Nuthulaganti, P, Chambers, J, Sarau, HM, Bergsma, DJ, Herrity, NC, Buckley, PT, Muccitelli, RM, Dytko, GM, Elshourbagy, N, Wilson, S, Halsey, W, Murdock, PR, Sathe, G, Ames, RS, Hay, DW, Foley, JJ, Schmidt, DB, Ellis, C	Mol Pharmacol	1999
10391245	Characterization of the human cysteinyl leukotriene CysLT1 receptor Hooks, SB, Zeng, Z, Bai, C, Sawyer, N, Connolly, BM, Caskey, CT, Figueroa, DJ, Im, DS, Austin, CP, Ford-Hutchinson, AW, Metters, KM, Evans, JF, Chateauneuf, A, Williams DL, Jr, Stocco, R, Hosfield, E, Kargman, S, Greig, GM, Abramovitz, M, Liu, Q, Lynch, KR, Coulombe, N, O'Neill, GP	Nature	1999