SOX9 binds the SOX9 gene

Stable Identifier
R-HSA-9690395
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SOX9 binds the SOX9 gene
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SOX9 together with NR5A1 (SF1) binds the TES enhancer and other enhancers upstream of the SOX coding region (Croft et al. 2018 and inferred from mouse homologs) and thereby activates its own expression. As SRY expression decreases during testis differentiation, SOX9 and, later, DMRT1 become responsible for maintaining expression of SOX9.
Literature References
PubMed ID Title Journal Year
30552336 Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9

Croft, B, Ohnesorg, T, Hewitt, J, Bowles, J, Quinn, A, Tan, J, Corbin, V, Pelosi, E, van den Bergen, J, Sreenivasan, R, Knarston, I, Robevska, G, Vu, DC, Hutson, J, Harley, V, Ayers, K, Koopman, P, Sinclair, A

Nat Commun 2018
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Inferred From
Sox9 binds the Sox9 gene (Mus musculus)
Authored
May, B  (2020-05-24)
Reviewed
Kanai, Y  (2020-10-29)
Imaimatsu, K  (2020-10-29)
Created
May, B  (2020-05-31)
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