nsp8 binds MAP1LC3B

Stable Identifier
R-HSA-9687121
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The replicase polyprotein 1a of the human severe acute respiratory syndrome coronavirus (SARS-CoV) is post-translationally cleaved by virally encoded proteases to generate non-structural proteins (nsps). Viral nsps induce the formation of ER-bound double membrane vesicles (DMV) in host cells post infection. These DMVs are decorated with microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) proteins that are involved in autophagosome formation. However, there is no evidence that DMVs are recruited to the autophagy machinery. Immunofluorescence studies show that nsp8 colocalizes with MAP1LC3B suggesting a binding event (Prentice E. et al 2004).

Literature References
PubMed ID Title Journal Year
15331731 Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins

Prentice, E, McAuliffe, J, Lu, X, Subbarao, K, Denison, MR

J. Virol. 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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