8b binds to MAP1LC3B

Stable Identifier
R-HSA-9687109
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
8b binds to MAP1LC3B
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

It is known that non-structural proteins (nsp) in SARS-CoV viruses induce the formation of ER-bound double membrane vesicles (DMV) in host cells post infection. These DMVs are decorated with microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) proteins that are involved in autophagosome formation. However, there is no evidence that DMVs are recruited to the autophagy machinery. Studies show that in some cells sars8b (8b) colocalizes with MAP1LC3B. However, little is known about underlying molecular mechanisms (Shi C S. et al 2019).

Literature References
PubMed ID Title Journal Year
31231549 SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes

Shi, CS, Nabar, NR, Huang, NN, Kehrl, JH

Cell Death Discov 2019
Participants
Input
Output
Participant Of
hasEvent
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Varusai, TM  (2020-05-06)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Varusai, TM  (2020-05-06)
Cite Us!