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8b binds MAP1LC3B
Stable Identifier
R-HSA-9687109
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
8b binds MAP1LC3B (Homo sapiens)
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It is known that non-structural proteins (nsp) in SARS-CoV viruses induce the formation of ER-bound double membrane vesicles (DMV) in host cells post infection. These DMVs are decorated with microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) proteins that are involved in autophagosome formation. However, there is no evidence that DMVs are recruited to the autophagy machinery. Studies show that in some cells sars8b (8b) colocalizes with MAP1LC3B. However, little is known about underlying molecular mechanisms (Shi C S. et al 2019).
Literature References
PubMed ID
Title
Journal
Year
31231549
SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes
Shi, CS
,
Kehrl, JH
,
Huang, NN
,
Nabar, NR
Cell Death Discov
2019
Participants
Input
8b [cytosol]
(Human SARS coronavirus)
MAP1LC3B [cytosol]
(Homo sapiens)
Output
8b:MAP1LC3B [cytosol]
(Homo sapiens)
Participates
as an event of
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Disease
Name
Identifier
Synonyms
severe acute respiratory syndrome
DOID:2945
SARS-CoV infection, SARS
Authored
Varusai, TM (2020-05-06)
Reviewed
Acencio, ML (2020-05-27)
Mazein, A (2020-05-27)
Created
Varusai, TM (2020-05-06)
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