8b binds MAP1LC3B

Stable Identifier
R-HSA-9687109
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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8b binds MAP1LC3B
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It is known that non-structural proteins (nsp) in SARS-CoV viruses induce the formation of ER-bound double membrane vesicles (DMV) in host cells post infection. These DMVs are decorated with microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) proteins that are involved in autophagosome formation. However, there is no evidence that DMVs are recruited to the autophagy machinery. Studies show that in some cells sars8b (8b) colocalizes with MAP1LC3B. However, little is known about underlying molecular mechanisms (Shi C S. et al 2019).
Literature References
PubMed ID Title Journal Year
31231549 SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes

Shi, CS, Kehrl, JH, Huang, NN, Nabar, NR

Cell Death Discov 2019
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Varusai, TM  (2020-05-06)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Varusai, TM  (2020-05-06)
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