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RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
Stable Identifier
R-HSA-9686978
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RB1:SKP2:APC/C:FZR1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17187060
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
Binné, UK
,
Kaelin, WG
,
Rape, M
,
Classon, MK
,
Wei, W
,
Dyson, NJ
,
Dick, FA
,
Näär, AM
Nat. Cell Biol.
2007
Participants
components
Cdh1:phospho-APC/C complex [nucleoplasm]
(Homo sapiens)
RB1 [nucleoplasm]
(Homo sapiens)
SKP2 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
RB1 recruits APC/C:Cdh1 complex to SKP2 (Homo sapiens)
as an input of
APC/C:Cdh1 polyubiquitinates SKP2 (Homo sapiens)
Inferred To
RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
(Bos taurus)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
(Canis familiaris)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
(Dictyostelium discoideum)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
(Drosophila melanogaster)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
(Gallus gallus)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
(Mus musculus)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
(Rattus norvegicus)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
(Sus scrofa)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
(Xenopus tropicalis)
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