Reactome | RIPK3 is cleaved by CASP8

RIPK3 is cleaved by CASP8

Stable Identifier

R-HSA-9686930

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Caspase-8 (CASP8) in human and rodent cells facilitates the cleavage of receptor-interacting protein kinases RIPK1 and RIPK3 and prevents RIPK1/RIPK3-dependent regulated necrosis (Lin Y et al. 1999; Hopkins-Donaldson S et al. 2000). These cleavage sites are identified to be Asp324 in RIPK1 and Asp328 in RIPK3 in humans (Lin Y et al. 1999; Feng S et al. 2007). The lack of CASP8 proteolytic activity in the presence of viral (e.g. CrmA and vICA) or pharmacological caspase inhibitors results in necroptosis induction via RIPK1 and RIPK3 (Tewari M & Dixit VM 1995; Fliss PM & Brune W 2012; Hopkins-Donaldson S et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
17644308	Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain Feng, S, Yang, Y, Mei, Y, Ma, L, Zhu, DE, Hoti, N, Castanares, M, Wu, M	Cell. Signal.	2007