TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis

Stable Identifier
R-HSA-9686731
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
plasma membrane
ReviewStatus
5/5
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TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis
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Transmembrane protease serine 2 (TMPRSS2), associated with the plasma membrane of the host cell, mediates the hydrolytic cleavage of SARS-CoV-1 Spike (S) protein component of the viral membrane-associate S3:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer complex associated with ACE2 (Matsuyama et al. 2010; Glowacka et al. 2011; Shulla et al. 2011).
Literature References
PubMed ID Title Journal Year
20926566 Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2

Kawase, M, Nagata, N, Shirato, K, Matsuyama, S, Takeda, M, Taguchi, F

J. Virol. 2010
21068237 A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

Perlman, S, Shulla, A, Zhao, J, Gallagher, T, Heald-Sargent, T, Subramanya, G

J. Virol. 2011
21325420 Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response

Glowacka, I, Drosten, C, Niemeyer, D, He, Y, Bertram, S, Steffen, I, Müller, MA, Gnirss, K, Soilleux, E, Pöhlmann, S, Tsegaye, TS, Pfefferle, S, Allen, P, Schneider, H

J. Virol. 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of TMPRSS2 [plasma membrane]

Physical Entity
TMPRSS2 [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
This event is regulated
Negatively by
Regulator
TMPRSS2:TMPRSS2 inhibitors [plasma membrane] (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Gillespie, ME  (2020-05-05)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Gillespie, ME  (2020-05-05)
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