Nucleoprotein is ADP-ribosylated

Stable Identifier
R-HSA-9686061
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
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Nucleoprotein (N) is ADP-ribosylated. The modification is maintained both in the cell and in virions (Grunewald et al, 2018). Members of the protein mono-ADP-ribosyltransferase (PARP) enzyme family are thought to catalyze this reaction (Fehr et al. 2020).

Literature References
PubMed ID Title Journal Year
29199039 The coronavirus nucleocapsid protein is ADP-ribosylated

Grunewald, ME, Fehr, AR, Athmer, J, Perlman, S

Virology 2018
32029454 The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions

Fehr, AR, Singh, SA, Kerr, CM, Mukai, S, Higashi, H, Aikawa, M

Genes Dev. 2020
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD+ ADP-ribosyltransferase activity of PARPs [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Created
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