nsp3 binds to nsp7-8 and nsp12-16

Stable Identifier
R-HSA-9686005
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
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On the final assembly, proteomics data suggest that the NAB−βSM−TM1 domains of nsp3 can interact with nsp7 − 8, as well as nsps 12–16, and the domain Y1 plus CoV-Y interacts with nsp9 and nsp12 (Imbert et al., 2008). Also a PL2pro−NAB−βSM−TM1 construct of Nsp3 can bind Nsp4 and Nsp12, while the region from TM1 to the end of Nsp3 only binds Nsp8 (Pan et al., 2008).

Literature References
PubMed ID Title Journal Year
18827877 Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication

Pan, J, Peng, X, Gao, Y, Li, Z, Lu, X, Chen, Y, Ishaq, M, Liu, D, DeDiego, ML, Enjuanes, L, Guo, D

PLoS ONE 2008
18255185 The SARS-Coronavirus PLnc domain of nsp3 as a replication/transcription scaffolding protein

Imbert, I, Snijder, EJ, Dimitrova, M, Guillemot, JC, Lécine, P, Canard, B

Virus Res. 2008
Participants
Participates
Orthologous Events
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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