Endocytosis of protein 3a

Stable Identifier
Reaction [uncertain]
Homo sapiens
Related Species
Human SARS coronavirus
Locations in the PathwayBrowser
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Protein 3a is rapidly internalized into cells by endocytosis. It contains a Yxxφ motif and also diacidic motifs which are typically found in internalized membrane proteins (Tan et al, 2004). The ability to be internalized is necessary for the protein's pro-apoptotic function (Wong et al, 2006; Chan et al, 2009).
Literature References
PubMed ID Title Journal Year
16212942 In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila

Chui, YL, Chen, Y, Fung, KP, Chan, CM, Chan, PK, Chan, HY, Chan, CS, Tsui, SK, Wong, SL, Waye, MM

Biochem. Biophys. Res. Commun. 2005
19398035 The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function

Zhai, S, Tsoi, H, Tsui, SK, Yao, X, Chan, CM, Wong, CO, Chan, WM, Chan, WY, Chan, HY

Int. J. Biochem. Cell Biol. 2009
15194747 A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis

Tan, TH, Hong, W, Teng, E, Tan, YJ, Fielding, BC, Ooi, EE, Lim, SG, Tan, HC, Shen, S, Goh, PY

J. Virol. 2004
Orthologous Events
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
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