SARS virus buds into ERGIC lumen

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Human SARS coronavirus
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Interaction of the ribonucleocapsid and the structural proteins in the ERGIC membrane promotes the formation of virions by budding into to the ERGIC lumen (reviewed in Masters, 2006). Coronavirus membrane curvature is driven by M lattice formation, interaction with the nucleocapsid and by E protein (de Haan et al, 1998; de Haan et al, 2000; Hsieh et al, 2005; Hsieh et al, 2008; reviewed in Masters, 2006; Ujike and Taguchi, 2015; Schoeman and Fielding 2019).
Literature References
PubMed ID Title Journal Year
16254320 Assembly of severe acute respiratory syndrome coronavirus RNA packaging signal into virus-like particles is nucleocapsid dependent

Hsieh, PK, Chang, CK, Lee, TT, Hsiao, CW, Huang, CC, Chen, IY, Kou, YH, Chang, MF, Huang, TH, Chang, SC

J. Virol. 2005
9658133 Coronavirus particle assembly: primary structure requirements of the membrane protein

Kuo, L, de Haan, CA, Rottier, PJ, Masters, PS, Vennema, H

J. Virol. 1998
31133031 Coronavirus envelope protein: current knowledge

Schoeman, D, Fielding, BC

Virol. J. 2019
25855243 Incorporation of spike and membrane glycoproteins into coronavirus virions

Ujike, M, Taguchi, F

Viruses 2015
18792806 Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus

Chen, SC, Li, HC, Lo, SY, Hsieh, YC

J. Biomed. Sci. 2008
10799570 Assembly of the coronavirus envelope: homotypic interactions between the M proteins

de Haan, CA, Rottier, PJ, Vennema, H

J. Virol. 2000
16877062 The molecular biology of coronaviruses

Masters, PS

Adv. Virus Res. 2006
Orthologous Events
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
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