SARS-CoV-1 9b recruits ITCH to MAVS

Stable Identifier
R-HSA-9685195
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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SARS-CoV-1 9b recruits ITCH to MAVS
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On viral infection poly(rC) binding protein 2 (PCBP2) binds mitochondrial antiviral signaling protein (MAVS or IPS-1) and recruits the HECT domain-containing E3 ligase AIP4 (or ITCH) (You F et al. 2009). ITCH catalyses K48-linked polyubiquitination to trigger degradation of MAVS via the proteasomal pathway. Severe acute respiratory syndrome coronavirus-1 (SARS-CoV-1) 9b (ORF9b) suppresses the MAVS-mediated signaling pathway by facilitating the recruitment of PCBP2 and ITCH to MAVS during viral infection (Shi CS et al. 2014).
Literature References
PubMed ID Title Journal Year
25135833 SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome

Shi, CS, Qi, HY, Boularan, C, Huang, NN, Abu-Asab, M, Shelhamer, JH, Kehrl, JH

J. Immunol. 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of ITCH [cytosol]

Physical Entity
ITCH [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Cross References
Mondo
Authored
Shamovsky, V  (2020-06-25)
Reviewed
D'Eustachio, P  (2021-01-26)
Created
Shamovsky, V  (2020-04-23)
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