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SARS-CoV-1 9b binds MAVS and PCBP2
Stable Identifier
R-HSA-9685189
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
,
mitochondrial outer membrane
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 9b binds MAVS and PCBP2 (Homo sapiens)
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The severe acute respiratory syndrome coronavirus type 1 (SARS-CoV-1) open reading frame-9b protein (ORF-9b or 9b) is an accessory protein that may have a function during virus assembly (Xu K, et al. 2009) and may influence virus-host interplay and pathogenesis (Shi CS et al. 2014; Jiang HW et al. 2020). SARS-CoV-1 9b is highly homologous to SARS-CoV-2 9b (Jiang HW et al. 2020; Gordon DE et al. 2020). Viral 9b of both SARS-CoV-1 and SARS-CoV-2 were found to localize to the membrane of mitochondria to suppress host innate immunity (Shi CS et al. 2014; Jiang HW et al. 2020; Gordon DE et al. 2020). Viral 9b targets the mitochondrial antiviral signaling protein (MAVS) signalosome (Shi CS et al. 2014). 9b was shown to recruit poly(rC) binding protein 2 (PCBP2) and the HECT domain E3 ligase AIP4 (ITCH) to trigger the K48-linked polyubiquitination and subsequent degradation of MAVS via the proteasomal pathway (Shi CS et al. 2014). The structural studies revealed that viral 9b forms a 2-fold symmetric dimer constructed from two adjacent twisted β sheets with an amphipathic surface, and a central hydrophobic cavity that is thought to be involved in membrane attachment (Meier C et al. 2006). Self-interactions of 9b were also shown by co-immunoprecipitation (CoIP) assay in human embryonic kidney (HEK 293T) cells (von Brunn A et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
25135833
SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome
Abu-Asab, M
,
Shi, CS
,
Kehrl, JH
,
Huang, NN
,
Shelhamer, JH
,
Qi, HY
,
Boularan, C
J. Immunol.
2014
Participants
Input
9b homodimer [mitochondrial outer membrane]
(Human SARS coronavirus)
MAVS [mitochondrial outer membrane]
(Homo sapiens)
PCBP2 [cytosol]
(Homo sapiens)
Output
9b:PCBP2:MAVS [mitochondrial outer membrane]
(Homo sapiens)
Participates
as an event of
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
Disease
Name
Identifier
Synonyms
severe acute respiratory syndrome
DOID:2945
SARS-CoV infection, SARS
Authored
Shamovsky, V (2020-06-25)
Reviewed
D'Eustachio, P (2021-01-26)
Created
Shamovsky, V (2020-04-23)
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