nsp3-4 cleaves itself

Stable Identifier
R-HSA-9684352
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
Locations in the PathwayBrowser
General
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To process the nsp3/4 cleavage site, PL-PRO and, presumably, nsp3-4 need to be glycosylated and localized to a membrane (Harcourt et al, 2004)

Literature References
PubMed ID Title Journal Year
15564471 Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

Harcourt, BH, Jukneliene, D, Kanjanahaluethai, A, Bechill, J, Severson, KM, Smith, CM, Rota, PA, Baker, SC

J. Virol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of N-glycan pp1ab-nsp3-4 [endoplasmic reticulum membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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