nsp1-4 cleaves itself

Stable Identifier
R-HSA-9684336
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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The papain-like protease domain of the nsp1-4 fragment alone is sufficient for processing the nsp1/2 and nsp2/3 cleavage sites (Harcourt et al, 2004)

Literature References
PubMed ID Title Journal Year
15564471 Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

Harcourt, BH, Jukneliene, D, Kanjanahaluethai, A, Bechill, J, Severson, KM, Smith, CM, Rota, PA, Baker, SC

J. Virol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of pp1a-nsp1-4 [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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