nsp1-4 cleaves itself

Stable Identifier
R-HSA-9684336
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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nsp1-4 cleaves itself
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The papain-like protease domain of the nsp1-4 fragment alone is sufficient for processing the nsp1/2 and nsp2/3 cleavage sites (Harcourt et al, 2004)
Literature References
PubMed ID Title Journal Year
15564471 Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

Harcourt, BH, Jukneliene, D, Kanjanahaluethai, A, Bechill, J, Severson, KM, Smith, CM, Rota, PA, Baker, SC

J. Virol. 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of pp1a-nsp1-4 [cytosol]

Physical Entity
pp1a-nsp1-4 [cytosol] (Human SARS coronavirus)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
nsp1-4 cleaves itself (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Cross References
Mondo
Authored
Stephan, R  (2020-04-14)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Stephan, R  (2020-04-21)
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