nsp1-4 cleaves itself

Stable Identifier
R-HSA-9684336
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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The papain-like protease domain of the nsp1-4 fragment alone is sufficient for processing the nsp1/2 and nsp2/3 cleavage sites (Harcourt et al, 2004)
Literature References
PubMed ID Title Journal Year
15564471 Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

Severson, KM, Baker, SC, Jukneliene, D, Rota, PA, Harcourt, BH, Smith, CM, Bechill, J, Kanjanahaluethai, A

J. Virol. 2004
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of pp1a-nsp1-4 [cytosol]

Orthologous Events
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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