3CLp forms a homodimer

Stable Identifier
R-HSA-9684323
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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3CLp forms a homodimer
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The main protease has no post-translational modifications. Most of it is in monomeric form, but only the dimer shows cysteine endopeptidase activity (Sun et al, 2003; Fan et al, 2004)
Literature References
PubMed ID Title Journal Year
14561748 Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase

Chen, J, Liu, Y, Lai, B, Wei, P, Ma, L, Feng, Q, Fan, K, Lai, L, Pei, J, Huang, C, Chen, S

J. Biol. Chem. 2004
14965777 Molecular cloning, expression, purification, and mass spectrometric characterization of 3C-like protease of SARS coronavirus

Wang, Y, Yang, Y, Peng, S, Xie, Y, Yu, C, Jiang, H, Sun, H, Chen, K, Shen, J, Qin, J, Chen, J, Shen, X, Luo, H, Sun, T

Protein Expr. Purif. 2003
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-14)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Stephan, R  (2020-04-21)
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