3CLp forms a homodimer

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Human SARS coronavirus
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
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The main protease has no post-translational modifications. Most of it is in monomeric form, but only the dimer shows cysteine endopeptidase activity (Sun et al, 2003; Fan et al, 2004)

Literature References
PubMed ID Title Journal Year
14965777 Molecular cloning, expression, purification, and mass spectrometric characterization of 3C-like protease of SARS coronavirus

Sun, H, Luo, H, Yu, C, Sun, T, Chen, J, Peng, S, Qin, J, Shen, J, Yang, Y, Xie, Y, Chen, K, Wang, Y, Shen, X, Jiang, H

Protein Expr. Purif. 2003
14561748 Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase

Fan, K, Wei, P, Feng, Q, Chen, S, Huang, C, Ma, L, Lai, B, Pei, J, Liu, Y, Chen, J, Lai, L

J. Biol. Chem. 2004
Participant Of
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
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