Trimmed spike protein binds to calnexin

Stable Identifier
R-HSA-9683772
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
Locations in the PathwayBrowser
General
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Calnexin transiently binds the unfolded spike protein and prevents its aggregation and premature degradation, ensuring its correct folding (Fukushi et al, 2012)

Literature References
PubMed ID Title Journal Year
22915798 Monitoring of S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome coronavirus

Fukushi, M, Yoshinaka, Y, Matsuoka, Y, Hatakeyama, S, Ishizaka, Y, Kirikae, T, Sasazuki, T, Miyoshi-Akiyama, T

J. Virol. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
unfolded protein binding activity of CANX [endoplasmic reticulum lumen]
Physical Entity
Activity
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Created
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