Spike protein gets N-glycosylated

Stable Identifier
R-HSA-9683755
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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Spike protein gets N-glycosylated
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Glycosyltransferases in the endoplasmatic reticulum are responsible for the attachment of numerous high-mannose N-glycans on the SARS-CoV-1 spike protein. After virion assembly and release these glycosidations are required for fusion with host cells (Krokhin et al, 2003; Nal et al, 2005; Ritchie et al, 2010).
Literature References
PubMed ID Title Journal Year
20129637 Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein

Feldmann, H, Feldmann, F, Rudd, PM, Stroeher, U, Royle, L, Harvey, DJ, Dwek, RA, Ritchie, G

Virology 2010
Participants
Input
Output
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as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-08)
Created
Stephan, R  (2020-04-17)
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