N-glycan trimming of Spike

Stable Identifier
R-HSA-9683663
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
Locations in the PathwayBrowser
General
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N-glycan side chains on the nascent SARS-CoV-1 spike protein get their terminal glucose moieties cleaved by ER glucosidases I and II, before folding. Iminosugars inhibit this process and are good candidates for broad-spectrum anivirals (Zhao et al, 2015).

Literature References
PubMed ID Title Journal Year
25348530 Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2

Zhao, X, Guo, F, Comunale, MA, Mehta, A, Sehgal, M, Jain, P, Cuconati, A, Lin, H, Block, TM, Chang, J, Guo, JT

Antimicrob. Agents Chemother. 2015
Participants
Participates
Catalyst Activity

glucan 1,3-alpha-glucosidase activity of ER alpha-glucosidases [endoplasmic reticulum lumen]

This event is regulated
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Created
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