Spike trimer glycoside chains are extended

Stable Identifier
R-HSA-9683648
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
endoplasmic reticulum-Golgi intermediate compartment
ReviewStatus
5/5
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Spike trimer glycoside chains are extended
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In the cis- to medial Golgis, conversion of high-mannose to complex type N-glycans side chains of Spike occurs. The N-acetylglucosaminyltransferase called GlcNAc-TI (MGAT1) adds a GlcNAc residue in the core of some high-mannose chains (Ritchie et al, 2010; Nal et al, 2005, Song et al, 2004).
Literature References
PubMed ID Title Journal Year
20129637 Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein

Ritchie, G, Harvey, DJ, Feldmann, F, Stroeher, U, Feldmann, H, Royle, L, Dwek, RA, Rudd, PM

Virology 2010
Participants
Input
Output
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as an event of
Catalyst Activity

acetylglucosaminyltransferase activity of MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Physical Entity
MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Activity
acetylglucosaminyltransferase activity (GO:0008375)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Cross References
Mondo
Authored
Stephan, R  (2020-04-08)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Stephan, R  (2020-04-17)
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