Spike trimer glycoside chains are extended

Stable Identifier
R-HSA-9683648
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
endoplasmic reticulum-Golgi intermediate compartment
ReviewStatus
5/5
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Spike trimer glycoside chains are extended
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In the cis- to medial Golgis, conversion of high-mannose to complex type N-glycans side chains of Spike occurs. The N-acetylglucosaminyltransferase called GlcNAc-TI (MGAT1) adds a GlcNAc residue in the core of some high-mannose chains (Ritchie et al, 2010; Nal et al, 2005, Song et al, 2004).

Literature References
PubMed ID Title Journal Year
20129637 Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein

Feldmann, H, Feldmann, F, Rudd, PM, Stroeher, U, Royle, L, Harvey, DJ, Dwek, RA, Ritchie, G

Virology 2010
Participants
Input
Output
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as an event of
Catalyst Activity

acetylglucosaminyltransferase activity of MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Physical Entity
MGAT1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Activity
acetylglucosaminyltransferase activity (GO:0008375)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-08)
Created
Stephan, R  (2020-04-17)
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