E pentamer is transported to the Golgi

Stable Identifier
R-HSA-9683635
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
endoplasmic reticulum membrane, Golgi membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
E pentamer is transported to the Golgi
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Both a predicted beta-hairpin motif and the N-terminal part of SARS-Cov protein E are sufficient for its localization to the Golgi membrane. Although porin activity has been shown for protein E it cannot be detected in the plasma membrane of infected cells (Liao et al, 2006; Cohen et al, 2011; Nieto-Torres, 2011).

Literature References
PubMed ID Title Journal Year
21450821 Identification of a Golgi complex-targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein

Lin, LD, Cohen, JR, Machamer, CE

J. Virol. 2011
21524776 Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein

Regla-Nava, JA, Jiménez-Guardeño, JM, DeDiego, ML, Enjuanes, L, Llorente, M, Shuo, S, Kremer, L, Alvarez, E, Nieto-Torres, JL

Virology 2011
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Stephan, R  (2020-04-08)
Created
Stephan, R  (2020-04-17)
Cite Us!