E pentamer is transported to the Golgi

Stable Identifier
Reaction [uncertain]
Homo sapiens
Related Species
Human SARS coronavirus
Locations in the PathwayBrowser
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Both a predicted beta-hairpin motif and the N-terminal part of SARS-Cov protein E are sufficient for its localization to the Golgi membrane. Although porin activity has been shown for protein E it cannot be detected in the plasma membrane of infected cells (Liao et al, 2006; Cohen et al, 2011; Nieto-Torres, 2011).

Literature References
PubMed ID Title Journal Year
21524776 Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein

Nieto-Torres, JL, DeDiego, ML, Alvarez, E, Jiménez-Guardeño, JM, Regla-Nava, JA, Llorente, M, Kremer, L, Shuo, S, Enjuanes, L

Virology 2011
21450821 Identification of a Golgi complex-targeting signal in the cytoplasmic tail of the severe acute respiratory syndrome coronavirus envelope protein

Cohen, JR, Lin, LD, Machamer, CE

J. Virol. 2011
Orthologous Events
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
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