There is a mixed population of mRNA3 clones having six, seven, eight and nine T stretches located 14 nt downstream of the initiation codon that occur in vivo. The transcribed Us practically act as slippery sequences in heterogenous ORFs. Translation efficiency is reduced in slipping clones, however (Thiel et al, 2003; Tan et al, 2005; Wang et al, 2006).
Thiel, V, Ivanov, KA, Putics, Á, Hertzig, T, Schelle, B, Bayer, S, Weißbrich, B, Snijder, EJ, Rabenau, H, Doerr, HW, Gorbalenya, AE, Ziebuhr, J
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