nsp14 binds nsp10

Stable Identifier
R-HSA-9682544
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
Locations in the PathwayBrowser
General
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nsp10 forms a stable complex with nsp14 (Bouvet et al. 2012) and serves as a co-factor for nsp14, stimulating its 3'->5' exonuclease activity (Bouvet et al. 2012, Subissi et al. 2014, Bouvet et al. 2014).

Literature References
PubMed ID Title Journal Year
25074927 Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

Bouvet, M, Lugari, A, Posthuma, CC, Zevenhoven, JC, Bernard, S, Betzi, S, Imbert, I, Canard, B, Guillemot, JC, L├ęcine, P, Pfefferle, S, Drosten, C, Snijder, EJ, Decroly, E, Morelli, X

J. Biol. Chem. 2014
22635272 RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

Bouvet, M, Imbert, I, Subissi, L, Gluais, L, Canard, B, Decroly, E

Proc. Natl. Acad. Sci. U.S.A. 2012
25197083 One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Subissi, L, Posthuma, CC, Collet, A, Zevenhoven-Dobbe, JC, Gorbalenya, AE, Decroly, E, Snijder, EJ, Canard, B, Imbert, I

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Participant Of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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