nsp14 binds nsp12

Stable Identifier
R-HSA-9682258
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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nsp14 binds nsp12
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Non-structural protein 14 (nsp14) of the human SARS coronavirus is a bifunctional enzyme bearing 3'-5 exoribonuclease activity involved in replication fidelity and RNA cap N7-guanine methyltransferase activity involved in 5'-RNA capping. nsp14 binds to the minimal replication and transcription complex (RTC), composed of nsp7, nsp8, and nsp12, by directly binding to nsp12 (the main RNA-dependent RNA polymerase). Binding of nsp14 does not affect the processivity of the RTC (Minskaia et al. 2006, Subissi et al. 2014).
Literature References
PubMed ID Title Journal Year
16549795 Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis

Campanacci, V, Canard, B, Hertzig, T, Minskaia, E, Gorbalenya, AE, Ziebuhr, J, Cambillau, C

Proc. Natl. Acad. Sci. U.S.A. 2006
25197083 One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Canard, B, Collet, A, Gorbalenya, AE, Subissi, L, Decroly, E, Imbert, I, Posthuma, CC, Zevenhoven-Dobbe, JC, Snijder, EJ

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Input
Output
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as an event of
Orthologous Events
nsp14 binds nsp12 (Homo sapiens)
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Orlic-Milacic, M  (2020-04-30)
Reviewed
Acencio, ML  (2020-05-27)
Mazein, A  (2020-05-27)
Created
Orlic-Milacic, M  (2020-04-08)
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