nsp14 binds nsp12

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Human SARS coronavirus
Locations in the PathwayBrowser
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Non-structural protein 14 (nsp14) of the human SARS coronavirus is a bifunctional enzyme bearing 3'-5 exoribonuclease activity involved in replication fidelity and RNA cap N7-guanine methyltransferase activity involved in 5'-RNA capping. nsp14 binds to the minimal replication and transcription complex (RTC), composed of nsp7, nsp8, and nsp12, by directly binding to nsp12 (the main RNA-dependent RNA polymerase). Binding of nsp14 does not affect the processivity of the RTC (Minskaia et al. 2006, Subissi et al. 2014).

Literature References
PubMed ID Title Journal Year
16549795 Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis

Campanacci, V, Canard, B, Hertzig, T, Minskaia, E, Gorbalenya, AE, Ziebuhr, J, Cambillau, C

Proc. Natl. Acad. Sci. U.S.A. 2006
25197083 One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Canard, B, Collet, A, Gorbalenya, AE, Subissi, L, Decroly, E, Imbert, I, Posthuma, CC, Zevenhoven-Dobbe, JC, Snijder, EJ

Proc. Natl. Acad. Sci. U.S.A. 2014
Orthologous Events
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
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