Reactome | AP2 binds chlorpromazine

AP2 binds chlorpromazine

Stable Identifier

R-HSA-9681616

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The human adaptor protein complex 2 (AP2) is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. Chlorpromazine was the first antipsychotic drug developed for the treatment of schizophrenia. Chlorpromazine is a cationic amphiphilic drug that disrupts clathrin-mediated endocytosis by inhibiting the relocation of clathrin and AP2 from the cell surface (Inoue et al. 2007, Yao et al. 2002). Chlorpromazine may also inhibit the replication of MERS and SARS viruses.

Literature References

PubMed ID	Title	Journal	Year
12429842	Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit Yao, D, Ehrlich, M, Henis, YI, Leof, EB	Mol. Biol. Cell	2002
17522231	Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted Inoue, Y, Tanaka, N, Tanaka, Y, Inoue, S, Morita, K, Zhuang, M, Hattori, T, Sugamura, K	J. Virol.	2007