AP2 binds chlorpromazine

Stable Identifier
R-HSA-9681616
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The human adaptor protein complex 2 (AP2) is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. Chlorpromazine was the first antipsychotic drug developed for the treatment of schizophrenia. Chlorpromazine is a cationic amphiphilic drug that disrupts clathrin-mediated endocytosis by inhibiting the relocation of clathrin and AP2 from the cell surface (Inoue et al. 2007, Yao et al. 2002). Chlorpromazine may also inhibit the replication of MERS and SARS viruses.

Literature References
PubMed ID Title Journal Year
17522231 Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted

Inoue, Y, Tanaka, N, Tanaka, Y, Inoue, S, Morita, K, Zhuang, M, Hattori, T, Sugamura, K

J. Virol. 2007
12429842 Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit

Yao, D, Ehrlich, M, Henis, YI, Leof, EB

Mol. Biol. Cell 2002
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