NS5B binds ribavirin

Stable Identifier
R-HSA-9680836
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Hepatitis C Virus
Compartment
cytosol
ReviewStatus
5/5
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NS5B binds ribavirin
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Ribavirin is a synthetic guanosine nucleoside and antiviral agent that interferes with the synthesis of viral mRNA, possessing a broad-spectrum activity against several RNA and DNA viruses (Crotty et al. 2000). It is primarily indicated for use in treating hepatitis C (HCV) and viral hemorrhagic fevers (Maag et al. 2001). Ribavirin is reported to have several mechanisms of actions that lead to inhibition of viral RNA and protein synthesis. After activation by adenosine kinase to ribavirin mono-, di-, and triphosphate metabolites, ribavirin triphosphate (RTP) is the predominant metabolite which directly inhibits viral mRNA polymerase by binding to the nucleotide binding site of the enzyme. Here, ribavirin binding to NS5B, the viral mRNA polymerase of HCV is annotated. This binding prevents the binding of the correct nucleotides, leading to a reduction in viral replication or to the production of defective virions (Te et al. 2007).

Ribavirin is currently being investigated for patients with COVID-19 (Chinese clinical trial registry no. ChiCTR2000029387) (Elfiky 2020).
Literature References
PubMed ID Title Journal Year
21960835 Mechanism of action of ribavirin in the treatment of chronic hepatitis C

Te, HS, Randall, G, Jensen, DM

Gastroenterol Hepatol (N Y) 2007
11100123 The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

Zhong, W, Lau, JY, Cameron, CE, Hong, Z, Andino, R, Crotty, S, Arnold, JJ, Maag, D

Nat. Med. 2000
32119961 Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

Elfiky, AA

Life Sci. 2020
11602568 Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin

Cameron, CE, Hong, Z, Castro, C, Maag, D

J. Biol. Chem. 2001
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Authored
Jassal, B  (2020-03-30)
Reviewed
Shoichet, BK  (2020-05-14)
Created
Jassal, B  (2020-03-30)
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