nsp12 binds nsp7 and nsp8

Stable Identifier
R-HSA-9680811
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
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The nsp7:nsp8 heterodimer binds to the RNA-directed RNA polymerase (nsp12) of the human SARS coronavirus on the polymerase thumb domain facing the NTP entry channel. Binding in this position sandwiches the RNA polymerase index finger loop between nsp7:nsp8 and the polymerase thumbdomain. The nsp7:nsp8 heterodimer may facilitate the interaction of the viral RNA polymerase with additional components of the RNA synthesis machinery. The second subunit of nsp8 interacts with the viral RNA polymerase interface domain proximal to the finger domain and the RNA template-binding channel, and is not bound to nsp7 (Kirchdoerfer and Ward 2019). This is consistent with the stoichiometry of the complex between feline coronavirus proteins nsp7, nsp8 and nsp12 (Xiao et al. 2012).

Literature References
PubMed ID Title Journal Year
31138817 Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

Kirchdoerfer, RN, Ward, AB

Nat Commun 2019
Participants
Participant Of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome 2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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