BRD4 binds fedratinib

Stable Identifier
R-HSA-9680408
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Bromodomain-containing protein 4 (BRD4) binds inhibitory small molecules including fedratinib, modifying or inhibiting its role in histone code reading via recognition of acetylated histones (Lucas et al. 2013). Fedratinib also binds and inhibits JAK2 (Ciceri et al. 2014), raising the possibility that this drug might target two aspects of host responses to coronavirus infection.

Literature References
PubMed ID Title Journal Year
24272870 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

Lucas, X, Wohlwend, D, Hügle, M, Schmidtkunz, K, Gerhardt, S, Schüle, R, Jung, M, Einsle, O, Günther, S

Angew. Chem. Int. Ed. Engl. 2013
24584101 Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

Ciceri, P, Müller, S, O'Mahony, A, Fedorov, O, Filippakopoulos, P, Hunt, JP, Lasater, EA, Pallares, G, Picaud, S, Wells, C, Martin, S, Wodicka, LM, Shah, NP, Treiber, DK, Knapp, S

Nat. Chem. Biol. 2014
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