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p-Y-GAB3 [cytosol]
Stable Identifier
R-HSA-9680365
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GRB2-associated-binding protein 3, GAB3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
GRB2-1:p-Y-GAB3 [cytosol] (Homo sapiens)
p-Y-GAB3 [cytosol] (Homo sapiens)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
GRB2-1:p-Y-GAB3 [cytosol] (Homo sapiens)
p-Y-GAB3 [cytosol] (Homo sapiens)
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)
GRB2-1:p-Y-GAB3 [cytosol] (Homo sapiens)
p-Y-GAB3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WWW8 GAB3
Gene Names
GAB3
Chain
chain:1-586
Reference Genes
BioGPS Gene:139716 GAB3
COSMIC (genes):GAB3 GAB3
CTD Gene:139716 GAB3
dbSNP Gene:139716 GAB3
ENSEMBL:ENSG00000160219 GAB3
ENSEMBL_homo_sapiens_GENE:ENSG00000160219.12 GAB3
HGNC:17515 GAB3
KEGG Gene (Homo sapiens):139716 GAB3
Monarch:139716 GAB3
NCBI Gene:139716 GAB3
OMIM:300482 GAB3
UCSC:Q8WWW8 GAB3
Reference Transcript
RefSeq:XM_006724804.1 GAB3
RefSeq:XM_005274648.1 GAB3
RefSeq:NM_080612.3 GAB3
RefSeq:NM_001282283.1 GAB3
RefSeq:NM_001081573.2 GAB3
Other Identifiers
11723911_a_at
139716
17115677
228410_PM_at
228410_at
4027542
4027543
4027545
4027549
4027551
4027553
4027554
4027556
4027557
4027558
4027559
4027560
4027562
4027563
4027570
4027571
56168_at
8176163
A_23_P255126
A_33_P3251369
GO:0005737
GO:0007165
GO:0023052
GO:0030154
GO:0030225
GO:0035591
GO:0048856
GO:0060090
HMNXSV003005058
HMNXSV003020237
HMNXSV003051922
Hs.102630.0.A1_3p_at
ILMN_1805979
PH_hs_0022331
TC0X001543.hg
Participates
as a component of
GRB2-1:p-Y-GAB3 [cytosol] (Homo sapiens)
Other forms of this molecule
GAB3 [cytosol]
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_006724867.1
,
NP_001075042.1
,
NP_001269212.1
,
NP_542179.1
,
XP_005274705.1
OpenTargets
ENSG00000160219
HPA
ENSG00000160219-GAB3
GeneCards
Q8WWW8
Ensembl
ENSP00000358581
,
ENSP00000399588
,
ENST00000369575
,
ENSP00000358588
,
ENST00000369568
,
ENST00000424127
,
ENSG00000160219
PRO
Q8WWW8
Pharos - Targets
Q8WWW8
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