Ligand-independent dimerization of KIT extracellular domain mutants

Stable Identifier
R-HSA-9680242
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Kit mutations in exon 8 and 9 affect the fifth Ig-like domain of the extracellular region, which is known to play an important role in dimer stabilization. Mutations in this region support ligand-independent dimerization of the receptor, leading to constitutive activation (Bodemer et al, 2010; Cammenga et al, 2005; Yuzawa et al, 2007; reviewed in Lennartsson and Roonstrand, 2012; Corless et al, 2011 ).

Literature References
PubMed ID Title Journal Year
19865100 Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations

Bodemer, C, Hermine, O, Palmérini, F, Yang, Y, Grandpeix-Guyodo, C, Leventhal, PS, Hadj-Rabia, S, Nasca, L, Georgin-Lavialle, S, Cohen-Akenine, A, Launay, JM, Barete, S, Feger, F, Arock, M, Catteau, B, Sans, B, Stalder, JF, Skowron, F, Thomas, L, Lorette, G, Plantin, P, Bordigoni, P, Lortholary, O, de Prost, Y, Moussy, A, Sobol, H, Dubreuil, P

J. Invest. Dermatol. 2010
23073628 Stem cell factor receptor/c-Kit: from basic science to clinical implications

Lennartsson, J, Rönnstrand, L

Physiol. Rev. 2012
22089421 Gastrointestinal stromal tumours: origin and molecular oncology

Corless, CL, Barnett, CM, Heinrich, MC

Nat. Rev. Cancer 2011
16081693 Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate

Cammenga, J, Horn, S, Bergholz, U, Sommer, G, Besmer, P, Fiedler, W, Stocking, C

Blood 2005
17662946 Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor

Yuzawa, S, Opatowsky, Y, Zhang, Z, Mandiyan, V, Lax, I, Schlessinger, J

Cell 2007
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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