Signaling by extracellular domain mutants of KIT

Stable Identifier
R-HSA-9680187
Type
Pathway
Species
Homo sapiens
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Many of the described KIT mutations are located in the fifth Ig-like domain, encoded by exon 8 and 9. The fifth Ig-like domain of KIT plays a critical role in stabilizing the receptor dimers formed upon SCF binding, allowing these mutations to support constitutive activation of the receptor (Yuzawa et al, 2007; reviewed in Lennartsson and Ronnstrand, 2012)

Literature References
PubMed ID Title Journal Year
17662946 Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor

Yuzawa, S, Opatowsky, Y, Zhang, Z, Mandiyan, V, Lax, I, Schlessinger, J

Cell 2007
23073628 Stem cell factor receptor/c-Kit: from basic science to clinical implications

Lennartsson, J, Rönnstrand, L

Physiol. Rev. 2012
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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