Reactome | p7Y-KIT S476N dimer [plasma membrane]

p7Y-KIT S476N dimer [plasma membrane]

Stable Identifier

R-HSA-9680160

Type

Complex

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by KIT in disease (Homo sapiens)
    - Signaling by extracellular domain mutants of KIT (Homo sapiens)
      - Phosphorylation of extracellular domain KIT mutants (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
    - Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
      - Dimerization of STATs downstream of KIT mutants (Homo sapiens)
        
        p-JAK2:SFKs:p-KIT mutants:p-STAT dimers [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
        
        p-JAK2:SFKs:p-KIT mutants:p-STATs [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
      - Disassociation and translocation of STATs to the nucleus downstream of KIT mutants (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
        
        p-JAK2:SFKs:p-KIT mutants:p-STAT dimers [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
      - JAK2 binds to p-KIT mutants (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs:JAK2 [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
      - KIT mutants bind GRB2-SOS (Homo sapiens)
        
        p-KIT mutants:GRB2:SOS [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
      - KIT mutants bind SFKs (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
      - KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
        
        PI3K:p-KIT mutant dimers [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
      - Phosphorylated KIT mutants bind PI3K (Homo sapiens)
        
        PI3K:p-KIT mutant dimers [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
      - Phosphorylation of JAK2 downstream of KIT mutants (Homo sapiens)
        
        KIT mutant dimers:SFKs:JAK2 [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
      - Phosphorylation of STATs downstream of KIT mutants (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
        
        p-JAK2:SFKs:p-KIT mutants:p-STATs [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
      - Recruitment of STATs by KIT mutants (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2:STATs [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs:p-JAK2 [plasma membrane] (Homo sapiens)
        
        KIT mutant dimers:SFKs [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)
      - p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS (Homo sapiens)
        
        p-KIT mutants:GRB2:SOS [plasma membrane] (Homo sapiens)
        
        p7Y-KIT kinase, extracellular and juxtamembrane domain dimers [plasma membrane] (Homo sapiens)
        
        p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)
        
        p7Y-KIT S476N dimer [plasma membrane] (Homo sapiens)

Participants

components

x 2 p7Y-KIT S476N [plasma membrane] (Homo sapiens)

Participates

as a candidate of

p7Y-extracellular domain mutants of KIT [plasma membrane] (Homo sapiens)

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

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