TBK1 binds amlexanox

Stable Identifier
R-HSA-9679819
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human alphaherpesvirus 2, Human cytomegalovirus
Compartment
cytosol
ReviewStatus
5/5
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TBK1 binds amlexanox
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The Serine/threonine-protein kinase TBK1 binds amlexanox, a small-molecule drug that reduces imflammatory processes associated with obesity (Reilly et al. 2013). TBK1 is a component of a signaling cascade that targets IRF3, which in turn appears to be a key mediator of the resistance observed in bats to symptoms of coronavirus infection (Banerjee et al. 2020).
Literature References
PubMed ID Title Journal Year
23396211 An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

Mowers, J, Decker, SJ, Li, P, Hochberg, I, Downes, M, Larsen, MJ, White, NM, Oh, D, Uhm, M, Chiang, SH, Reilly, SM, Chang, L, Olefsky, JM, Liddle, C, Evans, RM, Rubin, JR, Saltiel, AR, Yu, RT

Nat. Med. 2013
Participants
Input
Output
Participates
as an event of
Authored
Jassal, B  (2020-03-25)
Reviewed
Shoichet, BK  (2020-05-14)
Created
Jassal, B  (2020-03-25)
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