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ITGA4:ITGB1 binds natalizumab
Stable Identifier
R-HSA-9679740
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
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Integrins are the receptors that mediate cell adhesion to the extracellular matrix (ECM). They are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha-4 (ITGA4) is a receptor for fibronectin. ITGA4 functions as a heterodimer of an alpha subunit and the beta subunit of either the beta-1 chain or the beta-7 chain (ITGA4:ITGB1 shown here).
Natalizumab (Tysabri) is a humanised monoclonal antibody against the cell adhesion molecule α4-integrin. It is a medication used to treat multiple sclerosis and Crohn's disease (No authors 2004). It binds to the α4-subunit of α4b1 and α4b7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the α4-mediated adhesion of leukocytes to their counter-receptors. This is thought to reduce the ability of inflammatory immune cells to attach to and pass through the cell layers lining the intestines and blood–brain barrier (Rice et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
15851719
Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale
Hartung, HP
,
Calabresi, PA
,
Rice, GP
Neurology
2005
Participants
Input
ITGA4:ITGB1 [plasma membrane]
(Homo sapiens)
natalizumab [extracellular region]
Output
ITGA4:ITGB1:natalizumab [plasma membrane]
(Homo sapiens)
Participates
as an event of
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Orthologous Events
ITGA4:ITGB1 binds natalizumab (Bos taurus)
ITGA4:ITGB1 binds natalizumab (Caenorhabditis elegans)
ITGA4:ITGB1 binds natalizumab (Canis familiaris)
ITGA4:ITGB1 binds natalizumab (Danio rerio)
ITGA4:ITGB1 binds natalizumab (Drosophila melanogaster)
ITGA4:ITGB1 binds natalizumab (Gallus gallus)
ITGA4:ITGB1 binds natalizumab (Mus musculus)
ITGA4:ITGB1 binds natalizumab (Rattus norvegicus)
ITGA4:ITGB1 binds natalizumab (Sus scrofa)
ITGA4:ITGB1 binds natalizumab (Xenopus tropicalis)
Authored
Jassal, B (2020-03-25)
Reviewed
Shoichet, BK (2020-05-14)
Created
Jassal, B (2020-03-25)
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