NR3C1 binds NR3C1 agonists

Stable Identifier
R-HSA-9678925
Type
Reaction [binding]
Species
Homo sapiens
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Corticosteroids bind to the glucocorticoid receptor NR3C1 (Rupprecht et al. 1993, Lind et al. 2000), inhibiting pro-inflammatory NF-Kappa B and other inflammatory transcription factors, and promoting anti-inflammatory genes like interleukin-10. The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. From the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial in June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. In the trial, dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Literature References
PubMed ID Title Journal Year
10747884 Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding

Lind, U, Greenidge, P, Gillner, M, Koehler, KF, Wright, A, Carlstedt-Duke, J

J. Biol. Chem. 2000
8282004 Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands

Rupprecht, R, Reul, JM, van Steensel, B, Spengler, D, Söder, M, Berning, B, Holsboer, F, Damm, K

Eur. J. Pharmacol. 1993
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