NR3C1 binds NR3C1 agonists

Stable Identifier
Reaction [binding]
Homo sapiens
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Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals.

Literature References
PubMed ID Title Journal Year
8282004 Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands

Rupprecht, R, Reul, JM, van Steensel, B, Spengler, D, Söder, M, Berning, B, Holsboer, F, Damm, K

Eur. J. Pharmacol. 1993
21182429 Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay

Tajika, T, Waki, M, Tsuzuki, M, Kida, T, Sakaki, H

J Ocul Pharmacol Ther 2011
10633034 Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism

Biggadike, K, Angell, RM, Burgess, CM, Farrell, RM, Hancock, AP, Harker, AJ, Irving, WR, Ioannou, C, Procopiou, PA, Shaw, RE, Solanke, YE, Singh, OM, Snowden, MA, Stubbs, RJ, Walton, S, Weston, HE

J. Med. Chem. 2000
7472274 Species-related differences in steroid-binding specificity of glucocorticoid receptors in lung

Giannopoulos, G, Keichline, D

Endocrinology 1981
15878996 Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma

Belvisi, MG, Bundschuh, DS, Stoeck, M, Wicks, S, Underwood, S, Battram, CH, Haddad, el-B, Webber, SE, Foster, ML

J. Pharmacol. Exp. Ther. 2005
21880489 Design and synthesis of long acting inhaled corticosteroids for the treatment of asthma

Millan, DS, Ballard, SA, Chunn, S, Dybowski, JA, Fulton, CK, Glossop, PA, Guillabert, E, Hewson, CA, Jones, RM, Lamb, DJ, Napier, CM, Payne-Cook, TA, Renery, ER, Selby, MD, Tutt, MF, Yeadon, M

Bioorg. Med. Chem. Lett. 2011
10747884 Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding

Lind, U, Greenidge, P, Gillner, M, Koehler, KF, Wright, A, Carlstedt-Duke, J

J. Biol. Chem. 2000
7583234 Distinction between binding of [3H]triamcinolone acetonide to a ligand binding domain on the glucocorticoid receptor complex in cytosol fractions of brain and liver from the rat with intact adrenals

Yoneda, Y, Han, D, Ogita, K, Watanabe, A

Brain Res. 1995
10611474 Specific hydroxylations determine selective corticosteroid recognition by human glucocorticoid and mineralocorticoid receptors

Hellal-Levy, C, Couette, B, Fagart, J, Souque, A, Gomez-Sanchez, C, Rafestin-Oblin, M

FEBS Lett. 1999
28937774 Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases

Hemmerling, M, Nilsson, S, Edman, K, Eirefelt, S, Russell, W, Hendrickx, R, Johnsson, E, Kärrman Mårdh, C, Berger, M, Rehwinkel, H, Abrahamsson, A, Dahmén, J, Eriksson, AR, Gabos, B, Henriksson, K, Hossain, N, Ivanova, S, Jansson, AH, Jensen, TJ, Jerre, A, Johansson, H, Klingstedt, T, Lepistö, M, Lindsjö, M, Mile, I, Nikitidis, G, Steele, J, Tehler, U, Wissler, L, Hansson, T

J. Med. Chem. 2017
29424542 Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile

Ripa, L, Edman, K, Dearman, M, Edenro, G, Hendrickx, R, Ullah, V, Chang, HF, Lepistö, M, Chapman, D, Geschwindner, S, Wissler, L, Svanberg, P, Lawitz, K, Malmberg, J, Nikitidis, A, Olsson, RI, Bird, J, Llinas, A, Hegelund-Myrbäck, T, Berger, M, Thorne, P, Harrison, R, Köhler, C, Drmota, T

J. Med. Chem. 2018
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