Reactome | NR3C1 binds NR3C1 agonists

NR3C1 binds NR3C1 agonists

Stable Identifier

R-HSA-9678925

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Corticosteroids bind to the glucocorticoid receptor NR3C1 (Rupprecht et al. 1993, Lind et al. 2000), inhibiting pro-inflammatory NF-Kappa B and other inflammatory transcription factors, and promoting anti-inflammatory genes like interleukin-10. The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. From the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial in June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. In the trial, dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Literature References

PubMed ID	Title	Journal	Year
8282004	Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands Berning, B, van Steensel, B, Damm, K, Söder, M, Holsboer, F, Reul, JM, Spengler, D, Rupprecht, R	Eur. J. Pharmacol.	1993
10747884	Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding Lind, U, Wright, A, Koehler, KF, Gillner, M, Greenidge, P, Carlstedt-Duke, J	J. Biol. Chem.	2000