MAOB inhibitors bind MAOB:FAD

Stable Identifier
R-HSA-9677929
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Monoamine oxidase B inhibitors are used in depression and Parkinson's. Selegiline selective MAOB inhibitor.
Literature References
PubMed ID Title Journal Year
11159700 Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

Youdim, MB, Gross, A, Finberg, JP

Br. J. Pharmacol. 2001
15974574 Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors

Befani, O, Artico, M, Meninno, T, Palmegiani, P, Di Santo, R, Costi, R, La Torre, F, Roux, A, Cirilli, R, Agostinelli, E, Ferretti, R, Gallinella, B, Turini, P

J. Med. Chem. 2005
15027868 Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class

Sterling, J, Li, M, Mattevi, A, Edmondson, DE, Herzig, Y, Hubálek, F, Binda, C

J. Med. Chem. 2004
21377879 Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation

Sasmal, D, Mishra, N

Bioorg. Med. Chem. Lett. 2011
21680183 Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies

Sinha, BN, Ucar, G, Basu, A, Yabanoglu, S, Jagrat, M, Ercan, A, Jayaprakash, V, Behera, J, Sankaran, V

Bioorg. Med. Chem. Lett. 2011
24139167 1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases

Schlenk, M, Drabczyńska, A, Köse, M, Akkari, R, Koch, P, Küppers, P, Brunschweiger, A, Müller, CE, Hockemeyer, J, Kieć-Kononowicz, K, Radjainia, H, Borrmann, T

Bioorg. Med. Chem. 2013
15110846 Fluorinated phenylcyclopropylamines. Part 3: Inhibition of monoamine oxidase A and B

Rosen, TC, Ye, S, Sloan, MJ, Kirk, KL, Yoshida, S, Haufe, G, Meyer, OG

Bioorg. Med. Chem. 2004
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