CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN

Stable Identifier
Reaction [binding]
Homo sapiens
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The granulocyte colony-stimulating factor receptor (CSF3R, GCSFR, CD114) is a cell-surface receptor for the granulocyte colony-stimulating factor (CSF3, GCSF) (Fukunaga et al. 1990, Larsen et al. 1990). CSF3R is constitutively associated with the kinases LYN (Corey et al. 1994) and JAK1 (Nicholson et al. 1994) and is present on precursor cells in the bone marrow. CSF3 initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.
CSF3 exists as a dimer. Only the dimer of CSF3R exhibits high affinity binding to CSF3 (Hiraoka et al. 1994). CSF3R ligand-binding causes dimerization of the receptor (Aritomi et al. 1999, Tamada et al. 2006, Layton and Hall 2006) and signal transduction through JAK-STAT, RAS-RAF-ERK1,2, and PI3K.

Literature References
PubMed ID Title Journal Year
7805849 Evidence for the ligand-induced conversion from a dimer to a tetramer of the granulocyte colony-stimulating factor receptor

Ota, Y, Anaguchi, H, Hiraoka, O

FEBS Lett. 1994
1701053 Three different mRNAs encoding human granulocyte colony-stimulating factor receptor

Nagata, S, Mizushima, S, Fukunaga, R, Seto, Y

Proc. Natl. Acad. Sci. U.S.A. 1990
7512720 Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation

Oates, AC, Ziemiecki, A, Layton, JE, Nicholson, SE, Wilks, AF, Harpur, AG

Proc. Natl. Acad. Sci. U.S.A. 1994
8197119 Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases

Corey, SJ, Tweardy, DJ, Bolen, JB, Tkatch, LS, Burkhardt, AL, Geahlen, RL

Proc. Natl. Acad. Sci. U.S.A. 1994
10537111 Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme

Ota, Y, Aritomi, M, Kuroki, R, Morikawa, K, Kunishima, N, Okamoto, T

Nature 1999
2147944 Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains

Davis, T, Sorensen, E, Gimpel, S, Park, L, March, CJ, Larsen, A, Curtis, BM, Smith, CA, Cosman, D, Sims, JE

J. Exp. Med. 1990
16492764 Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex

Okamoto, T, Tamada, T, Tokunaga, M, Ishibashi, M, Kuroki, R, Maeda, Y, Honjo, E

Proc. Natl. Acad. Sci. U.S.A. 2006
Orthologous Events
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