Reactome | CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN

CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN

Stable Identifier

R-HSA-9677579

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN

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The granulocyte colony-stimulating factor receptor (CSF3R, GCSFR, CD114) is a cell-surface receptor for the granulocyte colony-stimulating factor (CSF3, GCSF) (Fukunaga et al. 1990, Larsen et al. 1990). CSF3R is constitutively associated with the kinases LYN (Corey et al. 1994) and JAK1 (Nicholson et al. 1994) and is present on precursor cells in the bone marrow. CSF3 initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.
CSF3 exists as a dimer. Only the dimer of CSF3R exhibits high affinity binding to CSF3 (Hiraoka et al. 1994). CSF3R ligand-binding causes dimerization of the receptor (Aritomi et al. 1999, Tamada et al. 2006, Layton and Hall 2006) and signal transduction through JAK-STAT, RAS-RAF-ERK1,2, and PI3K.

Literature References

PubMed ID	Title	Journal	Year
7805849	Evidence for the ligand-induced conversion from a dimer to a tetramer of the granulocyte colony-stimulating factor receptor Hiraoka, O, Anaguchi, H, Ota, Y	FEBS Lett.	1994
1701053	Three different mRNAs encoding human granulocyte colony-stimulating factor receptor Fukunaga, R, Seto, Y, Mizushima, S, Nagata, S	Proc. Natl. Acad. Sci. U.S.A.	1990
7512720	Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation Nicholson, SE, Oates, AC, Harpur, AG, Ziemiecki, A, Wilks, AF, Layton, JE	Proc. Natl. Acad. Sci. U.S.A.	1994
8197119	Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases Corey, SJ, Burkhardt, AL, Bolen, JB, Geahlen, RL, Tkatch, LS, Tweardy, DJ	Proc. Natl. Acad. Sci. U.S.A.	1994
10537111	Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme Aritomi, M, Kunishima, N, Okamoto, T, Kuroki, R, Ota, Y, Morikawa, K	Nature	1999
2147944	Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains Larsen, A, Davis, T, Curtis, BM, Gimpel, S, Sims, JE, Cosman, D, Park, L, Sorensen, E, March, CJ, Smith, CA	J. Exp. Med.	1990
16492764	Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex Tamada, T, Honjo, E, Maeda, Y, Okamoto, T, Ishibashi, M, Tokunaga, M, Kuroki, R	Proc. Natl. Acad. Sci. U.S.A.	2006