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SET1A complex [nucleoplasm]
Stable Identifier
R-HSA-9676258
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SETD1A:WRAD complex, SETD1A:WDR5:RBBP5:ASH2L:DPY30
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
Core MLL complex, SMYD3, PRDM9 [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Homo sapiens)
WHSC1L1, Core MLL complex, SMYD3, SETD3 [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
BOD1L1 binds SET1A complex (Homo sapiens)
BOD1L1:SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
CXXC1 and WDR82 bind SET1A complex (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
Formation of the SET1A complex (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
HCFC1 binds SET1A complex (Homo sapiens)
SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
SET1A complex:WDR82:CXXC1:HCFC1 [nucleoplasm] (Homo sapiens)
SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Core MLL complex [nucleoplasm] (Homo sapiens)
SET1A complex [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
22266653
The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases
Couture, JF
,
Brunzelle, JS
,
Zhang, P
,
Lee, H
Nucleic Acids Res.
2012
Participants
components
SETD1A [nucleoplasm]
(Homo sapiens)
WRAD complex [nucleoplasm]
(Homo sapiens)
Participates
as a component of
SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
as an input of
CXXC1 and WDR82 bind SET1A complex (Homo sapiens)
as an output of
Formation of the SET1A complex (Homo sapiens)
as a member of
Core MLL complex [nucleoplasm] (Homo sapiens)
Inferred To
SET1A complex [nucleoplasm]
(Bos taurus)
SET1A complex [nucleoplasm]
(Caenorhabditis elegans)
SET1A complex [nucleoplasm]
(Canis familiaris)
SET1A complex [nucleoplasm]
(Dictyostelium discoideum)
SET1A complex [nucleoplasm]
(Drosophila melanogaster)
SET1A complex [nucleoplasm]
(Mus musculus)
SET1A complex [nucleoplasm]
(Rattus norvegicus)
SET1A complex [nucleoplasm]
(Saccharomyces cerevisiae)
SET1A complex [nucleoplasm]
(Schizosaccharomyces pombe)
SET1A complex [nucleoplasm]
(Sus scrofa)
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