Reactome | Formation of the SET1A complex

Formation of the SET1A complex

Stable Identifier

R-HSA-9676257

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SETD1A (also known as SET1A) binds the WRAD complex, consisting of WDR5, RBBP5, ASH2L and DPY30, to form the SET1A complex (Zhang et al. 2012; van Nuland et al. 2013; Alicea-Velazquez et al. 2016). WDR5 plays an important role in the optimal stimulation of SET1A methyltransferase activity by the RBBP5:ASH2L heterodimer (Zhang et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23508102	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes van Nuland, R, Smits, AH, Pallaki, P, Jansen, PW, Vermeulen, M, Timmers, HT	Mol Cell Biol	2013
22266653	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases Zhang, P, Lee, H, Brunzelle, JS, Couture, JF	Nucleic Acids Res.	2012
27563068	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes Alicea-Velázquez, NL, Shinsky, SA, Loh, DM, Lee, JH, Skalnik, DG, Cosgrove, MS	J Biol Chem	2016