Reactome | Formation of the MLL2 complex

Formation of the MLL2 complex

Stable Identifier

R-HSA-9676255

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Cleaved KMT2B (also known as MLL2) dimers bind the WRAD complex, consisting of WDR5, RBBP5, ASH2L and DPY30, to form the MLL2 complex. WDR5 plays an important role in the optimal stimulation of MLL2 methyltransferase activity by the RBBP5:ASH2L heterodimer (Zhang et al. 2012, Jiang et al. 2013, Wei et al. 2021; Mayse et al. 2022).

MLL2 complex is responsible for H3K4 trimethylation (H3K4me3) on specific gene promotors and cis-regulatory sites (Jiang et al. 2013). These modifications play a role in regulating bivalent developmental genes and regulators involved in primordial germ cell specification during embryonic stem cell differentiation (reviewed in Klonou et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
35190547	Disentangling the recognition complexity of a protein hub using a nanopore Mayse, LA, Imran, A, Larimi, MG, Cosgrove, MS, Wolfe, AJ, Movileanu, L	Nat Commun	2022
23995757	Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95 Jiang, H, Lu, X, Shimada, M, Dou, Y, Tang, Z, Roeder, RG	Nat Struct Mol Biol	2013
34933446	GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation Wei, S, Lu, S, Liang, L, Wang, X, Li, W, Li, T, Chen, L, Ju, E, Zhang, X, Lai, Z, Huang, Y, Lu, X, Gao, SJ	mBio	2021
22266653	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases Zhang, P, Lee, H, Brunzelle, JS, Couture, JF	Nucleic Acids Res.	2012