CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2)

Stable Identifier
R-HSA-9674808
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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Proteins involved in RAS-RAF-ERK signaling bind the phosphorylated cytosolic domain of CSF3R (GCSFR) and are phosphorylated (Wang et al. 2008 and inferred from mouse homologs). GRB2, GAB2, and SHC1 bind phosphorylated CSF3R directly. PTPN11 (SHP2) directly binds the phosphorylated cytosolic domain of CSF3R (inferred from mouse homologs) and also appears to bind CSF3R indirectly via phosphorylated GAB2 (inferred from mouse homologs). LYN is required for phosphorylation of GAB2 9inferred from mouse homologs). The order of binding and phosphorylation is unknown.

Literature References
PubMed ID Title Journal Year
18644434 G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation

Wang, L, Xue, J, Zadorozny, EV, Robinson, LJ

Cell. Signal. 2008
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